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Related Experiment Videos

Percutaneous absorption and age. Implications for therapy.

K V Roskos1, H I Maibach

  • 1Controlled Release and Biomedical Polymers Department, SRI International, Menlo Park, California.

Drugs & Aging
|September 1, 1992
PubMed
Summary

As human skin ages, its barrier function changes, potentially affecting how medications are absorbed. This review examines age-related skin alterations and their impact on transdermal drug delivery efficacy.

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Area of Science:

  • Dermatology
  • Gerontology
  • Pharmacology

Background:

  • Human skin undergoes significant morphological, physiological, and biochemical changes with age.
  • Transdermal drug delivery is increasingly utilized for systemic effects.
  • The impact of skin aging on the penetration barrier and drug absorption remains unclear.

Purpose of the Study:

  • To review age-related changes in human skin from adulthood to old age.
  • To correlate these skin changes with clinical implications for dermatologists.
  • To evaluate existing data on age-related changes in skin barrier function and their relevance to percutaneous absorption.

Main Methods:

  • Literature review of published studies on skin aging.
  • Analysis of morphological, physiological, and biochemical skin changes.
  • Assessment of data on skin barrier function and percutaneous absorption in aged skin.

Main Results:

  • Skin aging involves documented morphological, physiological, and biochemical alterations.
  • Changes in aged skin may influence the percutaneous absorption of compounds.
  • Existing data suggest a potential alteration in the barrier function of aged human skin.

Conclusions:

  • Age-related changes in skin morphology and physiology can affect drug penetration.
  • Understanding these changes is crucial for optimizing transdermal drug delivery in older adults.
  • Further investigation is needed to fully elucidate the impact of skin aging on drug absorption and efficacy.

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