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Updated: Jun 4, 2026
19:56
Introduction to Solid Supported Membrane Based Electrophysiology
Published on: May 11, 2013
The sodium lauryl sulfate model: an overview
1Department of Dermatology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
Contact Dermatitis
|July 1, 1995
Summary
Sodium lauryl sulfate (SLS) is a practical model for studying irritant contact dermatitis. This review details methods for using SLS to investigate skin irritation mechanisms and future study designs.
Area of Science:
- Dermatology
- Toxicology
- Skin Science
Background:
- Irritant contact dermatitis presents diverse clinical forms and mechanisms.
- Sodium lauryl sulfate (SLS) is a widely adopted model for acute and cumulative irritation studies.
- Decades of research highlight SLS's utility in understanding skin irritation.
Purpose of the Study:
- To summarize research on Sodium lauryl sulfate (SLS) as a model for irritant contact dermatitis.
- To provide guidance on methodologies for future skin irritation studies.
- To detail SLS dosing, application techniques, and biological endpoints.
Main Methods:
- Review of several decades of scientific investigations.
- Analysis of different dosing and application methods (closed vs. open patch tests).
- Evaluation of biological endpoints such as visual grading and transepidermal water loss (TEWL).
Main Results:
- Sodium lauryl sulfate (SLS) has proven practical and informative for studying skin irritation.
- Established protocols exist for utilizing SLS in experimental settings.
- Various endpoints effectively measure skin irritation responses.
Conclusions:
- Sodium lauryl sulfate (SLS) remains a valuable tool for investigating irritant contact dermatitis.
- Standardized methodologies enhance the reliability of skin irritation studies.
- Further research can refine understanding and management of skin irritation.
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