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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
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Bone Remodeling and Repair01:31

Bone Remodeling and Repair

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Related Experiment Video

Updated: Jul 10, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Angiogenesis and osteogenesis in an orthopedically expanded suture

H N Chang1, L P Garetto, R H Potter

  • 1Department of Oral Facial Development, School of Dentistry, Indiana University School of Dentistry, Indianapolis 46202, USA.

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
|April 1, 1997
PubMed
Summary

Orthopedic expansion combined with recombinant human endothelial cell growth factor (rhECGF) significantly enhanced angiogenesis and osteogenic responses in rat sutures. Pericytes appear to be the origin of new osteoblasts during this process.

Keywords:
NASA Discipline MusculoskeletalNASA Discipline Number 40-40NASA Program Space BiologyNon-NASA Center

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Last Updated: Jul 10, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
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A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Area of Science:

  • Regenerative Medicine
  • Craniofacial Biology
  • Biomaterials Science

Background:

  • Sutural expansion is a therapeutic technique used in craniofacial surgery.
  • Understanding the cellular mechanisms driving bone regeneration post-expansion is crucial for optimizing treatment outcomes.

Purpose of the Study:

  • To investigate the angiogenic and osteogenic responses following orthopedic sutural expansion over a 96-hour period.
  • To determine the role of recombinant human endothelial cell growth factor (rhECGF) in enhancing these responses.

Main Methods:

  • Fifty rats were divided into control, experimental (expansion + rhECGF), sham (expansion + NaCl), and baseline groups.
  • Angiogenic induction was performed using rhECGF or NaCl.
  • Cell proliferation was assessed using 3H-thymidine labeling.
  • Angiogenesis and cell migration were analyzed using a cell kinetics model.
  • Histological analysis of demineralized sections stained with hematoxylin and eosin.

Main Results:

  • Experimental groups showed significant increases in blood vessel number, area, and endothelial cell proliferation compared to controls.
  • Supplemental rhECGF enhanced angiogenesis specifically in expanded sutures.
  • Labeled-pericyte index and activated pericyte numbers were elevated in the experimental group.
  • No significant differences in angiogenesis were observed between control and baseline groups.

Conclusions:

  • Supplemental rhECGF effectively enhances angiogenesis in orthopedically expanded sutures.
  • The findings suggest that pericytes are a primary source of osteoblasts during orthopedic expansion-induced osteogenesis.