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Inherited hypercoagulable states: questions and controversies

S Schenk, S H Goodnight

    Nurse Practitioner Forum
    |June 1, 1992
    PubMed

    Insights

    Inherited hypercoagulable states, including protein C, S, and antithrombin III deficiencies, contribute to recurrent blood clots. Risk assessment guides screening and anticoagulant use, especially during surgery and pregnancy.

    Area of Science:

    • Hematology
    • Genetics

    Background:

    • Inherited hypercoagulable states, such as deficiencies in protein C, protein S, and antithrombin III, are significant contributors to recurrent thromboembolic events, accounting for 15-20% of cases.
    • These genetic disorders share common risk factors that inform laboratory screening protocols.

    Purpose of the Study:

    • To outline the risk profile associated with inherited hypercoagulable states.
    • To guide the appropriate use of laboratory screening for these conditions.
    • To discuss the management of anticoagulation in patients with inherited hypercoagulable states, considering personal and family history.

    Main Methods:

    • Review of existing literature on inherited thrombophilia.
    • Analysis of risk factors and screening guidelines.
    • Discussion of anticoagulant therapy strategies.

    Main Results:

    • Identified a common risk profile for inherited hypercoagulable states.
    • Established the utility of laboratory screening based on risk factors.
    • Highlighted the variable need for anticoagulants based on thrombosis history.

    Conclusions:

    • Inherited deficiencies of protein C, S, and antithrombin III are key causes of recurrent thrombosis.
    • Risk stratification is essential for guiding screening and anticoagulant management.
    • Anticoagulant therapy requires individualized consideration, particularly in perioperative and pregnancy settings.

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