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Production and specificity of anti-22-oxacalcitriol antisera
N Kobayashi1, T Asano, J Kitahori
1Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
Chemical & Pharmaceutical Bulletin
|June 1, 1992
Abstract:
22-Oxacalcitriol 3-hemiglutarate, a haptenic derivative of 22-oxacalcitriol, was synthesized to obtain a specific antibody for use in radioimmunoassay. Three antisera were elicited in rabbits against the hapten conjugated with bovine serum albumin, and their specificity was examined by cross-reaction study. One of the antisera was found to be satisfactorily specific, and expected to provide a radioimmunoassay useful for the pharmacokinetic study of 22-oxacalcitriol.