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[Arterioembolization with shape memory angioembolus. Experimental study and clinical application].

¹Changhai Hospital, Second Military Medical University.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]

|February 1, 1992

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Nitinol-Conical Rugby Embolus (NT-CRE) effectively embolizes large arteries in dogs and humans. This shape memory device shows good biocompatibility and safe, rapid occlusion without complications.

Area of Science:

Biomaterials Science
Vascular Surgery
Medical Devices

Context:

Arterial embolization is crucial for treating various vascular conditions.
Existing embolic agents face limitations in large-bored arteries.
Novel embolic devices are needed for improved safety and efficacy.

Purpose:

To evaluate the experimental and clinical efficacy of the Nitinol-Conical Rugby Embolus (NT-CRE) for arterio-embolization.
To assess the histocompatibility and safety profile of the NT-CRE.
To determine the suitability of NT-CRE for large-bored arteries.

Summary:

The NT-CRE, a shape memory alloy angioembolus with a conical or rugby spiral configuration, demonstrated good histocompatibility in 20 dogs over 1-48 weeks.
In 7 human patients, NT-CRE successfully occluded target arteries (3.33-5.83 mm diameter) within 5-18 minutes.

Related Experiment Videos

The device's two-way memory effect and compact design facilitate simple, safe, and rapid catheterization and release.

Impact:

NT-CRE proves effective and safe for embolizing large-bored arteries, offering a reliable solution for vascular interventions.
The study highlights the potential of NT-CRE to reduce procedure time and improve patient outcomes.
No complications such as hemorrhage or misembolization were observed, suggesting a favorable safety profile.