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Chronic administration of cyclosporin A induces a decrease in hepatic excretory function in man.

J F Cadranel1, S Erlinger, M Desruenne

  • 1Service d'Hépatogastroentérologie, Hôpital de la Pitié-Salpétrière, Paris, France.

Digestive Diseases and Sciences
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

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Chronic cyclosporine A use in heart transplant patients significantly increased bile acid levels and bilirubin, while reducing liver excretory function compared to azathioprine. This suggests cyclosporine A impairs liver function.

Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Transplantation Medicine

Background:

  • Cyclosporine A (CsA) is an immunosuppressant used in organ transplantation.
  • Chronic CsA administration has been anecdotally linked to cholestasis in some patients.
  • Investigating CsA's impact on liver function is crucial for patient management.

Purpose of the Study:

  • To evaluate the effects of chronic cyclosporine A administration on liver excretory function.
  • To assess changes in serum bile acid levels, serum bilirubin concentration, and bromosulfophthalein (BSP) plasmatic fractional clearance.
  • To compare these parameters between CsA-treated heart transplant patients and azathioprine-treated kidney transplant patients.

Main Methods:

  • A comparative study involving 20 heart transplant patients on chronic CsA and 20 kidney transplant patients on azathioprine.

Related Experiment Videos

  • All patients had normal serum alanine aminotransferase activity at baseline.
  • Measurements included serum bile acids, serum bilirubin, and BSP plasmatic fractional clearance.

    • Main Results:

    • Cyclosporine A treatment was associated with a 32% increase in serum bile acid levels (P < 0.01).
    • Serum bilirubin concentration increased by 100% (P < 0.001) in CsA-treated patients.
    • Bromosulfophthalein plasmatic fractional clearance decreased by 60% (P < 0.001) with CsA use.

    Conclusions:

    • Chronic cyclosporine A administration significantly impairs hepatic excretory function in humans.
    • CsA treatment leads to elevated bile acid and bilirubin levels, indicative of cholestasis.
    • These findings highlight the potential hepatotoxicity of long-term cyclosporine A therapy.