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Genetic susceptibility to dermatophytosis
1Department of Dermatology, Guys Hospital, London, U.K.
European Journal of Epidemiology
|May 1, 1992
Summary
Inherited factors may influence susceptibility to dermatophytosis, a fungal skin infection. Genetic predisposition, particularly autosomal recessive inheritance, is suggested for some cases like tinea imbricata.
Area of Science:
- Medical Mycology
- Human Genetics
- Epidemiology
Background:
- Dermatophytosis epidemiology shows case clustering, suggesting non-environmental factors.
- Specific fungal infections like tinea imbricata (T. concentricum) may have genetic links.
- Associations exist between dermatophytosis and inherited human conditions.
Purpose of the Study:
- To explore the role of inherited susceptibility in dermatophytosis epidemiology.
- To investigate potential genetic mechanisms underlying susceptibility to fungal skin infections.
Main Methods:
- Review of epidemiological data on dermatophytosis clustering.
- Analysis of studies on T. concentricum infection and inheritance patterns.
- Examination of associations with other inherited disorders (atopy, candidosis, tylosis).
- Consideration of experimental data from animal models (mice).
Main Results:
- Clustering of dermatophytosis cases suggests a role for inherited susceptibility.
- Autosomal recessive inheritance is proposed for some T. concentricum infections, but not universally.
- Susceptibility varies across different inbred mouse strains, supporting genetic influence.
- Links observed between dermatophytosis and conditions like atopy and chronic mucocutaneous candidosis.
Conclusions:
- Inherited susceptibility likely contributes to the epidemiology of certain dermatophytosis forms.
- Genetic factors play a significant role in determining individual susceptibility to fungal skin infections.
- Further research into the specific genetic mechanisms is warranted.