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Lymphocyte subset and NK activity in cervical intra-epithelial neoplasia
G G Garzetti1, M Cignitti, A Ciavattini
1Department of Obstetrics and Gynaecology, University of Ancona, Italy.
Gynecologic and Obstetric Investigation
|January 1, 1992
Abstract:
We have studied the systemic T-lymphocyte subset and, in particular, the natural-killer (NK) activity in 23 patients with cervical intra-epithelial neoplasia (CIN), and 11 controls (a history of normal cervical PAP smears and colposcopy patterns). The lymphocyte phenotypes were studied using a panel of monoclonal antibodies, and NK activity was evaluated as the percentage lysis of K 562 target cells. In patients with CIN we found a significant decrease in NK activity (p = 0.002) which was directly correlated with the grade of CIN, with no alterations in the absolute number of NK cells.