[Morphogenesis of amyloidosis]

Basing on the literature data and findings of their own investigations with the use of sophisticated methods of morphological analysis, the authors showed that morphogenesis of experimental amyloidosis comprised the following links: 1) cellular transformations of the reticulo-endothelial system with formation of a clone of amyloidoblasts; 2) synthesis by these cells of protein of amyloid fibrils; 3) aggregation of fibrils with formation of a "carcass" of amyloid substance; 4) combination of aggregated fibrils with proteins and glucoproteids of plasma and also with acid mucopolysaccharides of the tissue and formation of a complex glucoproteid -- amyloid. The sources of amyloblasts in various organs were precursors of different cells of mesenchymal nature: in the spleen -- reticular and endothelial cells; in the liver -- Kupffer's cells; in the kidney -- mesangial and endothelial cells. In the course of formation of amyloid fibrils, the latter being anomalous protein of the body, a "competition" started between the synthesis of fibrillar protein and its resorption (amyloidoclasia). It completed in favour of the synthesis, which may be explained by the development of immunological tolerance to amyloid protein. At the final stage of amyloidogenesis of particular importance was an increase in the tissue-vascular permeability, which ensured the extracellular formation of amyloid substance and inclusion therein of hematogenic "additions" (fibrin', immune complexes, etc.).