[The variations of PRL, LH, FSH and testosterone in renal disease]

Blood PRL was measured with RIA in 22 males and 19 females with various degrees of renal insufficiency. At the same time, blood LH, FSH, testosterone were studied in all the male patients and 20 sex-age matched healthy subjects. The results showed that the levels of PRL and LH were increased, and the level of testosterone was decreased significantly in male uremic patients. There was a significant negative correlation between PRL and testosterone. All the above parameters were measured again 8-25 days after continuous ambulatory peritoneal dialysis (CAPD) therapy in 5 male uremic patients. The BUN and Cr levels decreased and the clinical manifestations of uremia improved, but the levels of PRL, LH, FSH and testosterone showed no significant changes. The mechanisms of these variations were discussed.