Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dysregulated proteolysis in AIDS.

D L Auci1, H G Durkin, M R Murali

  • 1Department of Pathology, State University of New York Health Science Center, Brooklyn 11203.

Immunological Investigations
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aphrodisiac Drug and Dental Health: A Systematic Review.

Journal of pharmacy & bioallied sciences·2026
Same author

Orphan Drugs and Diseases: A Systematic Review.

Journal of pharmacy & bioallied sciences·2026
Same author

Chlamydia pneumoniae induces interleukin-12 responses in peripheral blood mononuclear cells in asthma and the role of toll like receptor 2 versus 4: a pilot study.

Irish journal of medical science·2016
Same author

Increased seroprevalence of Enterovirus 71 IgE antibodies in asthmatic compared with non-asthmatic children.

Irish journal of medical science·2016
Same author

Coadministration of alloxan and nicotinamide in rats produces biochemical changes in blood and pathological alterations comparable to the changes in type II diabetes mellitus.

Human & experimental toxicology·2015
Same author

Gamma heavy chain disease: cytological diagnosis of a rare lymphoid malignancy facilitated by correlation with key laboratory findings.

Cytopathology : official journal of the British Society for Clinical Cytology·2014
Same journal

The Emerging Role of Tumor-Associated Neutrophils in Modulating Immune Checkpoint Inhibitor Response and Therapeutic Strategies.

Immunological investigations·2026
Same journal

Immune Reconstitution After Hematopoietic Stem Cell Transplantation: Cellular Dynamics, Clinical Determinants, and Emerging Therapeutic Strategies.

Immunological investigations·2026
Same journal

Riboflavin Modulates Complement Activation, Immune Cell Viability and Activation, and Neutrophil Microbicidal Functions <i>in Vitro</i>.

Immunological investigations·2026
Same journal

Pharmacological Modulation of Immunosenescence and Inflammaging: Senolytics, Senomorphics, and Emerging Therapies.

Immunological investigations·2026
Same journal

Nanoantibodies: A Review of Diagnostic and Therapeutic Applications in Respiratory Diseases.

Immunological investigations·2026
Same journal

TRIM31: A Novel Guardian Against Periodontal Inflammation via Modulation of NLRP3 Inflammasome and Macrophage Polarization.

Immunological investigations·2026
See all related articles

Serum from patients with acquired immunodeficiency syndrome (AIDS) showed reduced ability to inhibit urokinase (UK)-induced plasmin activity compared to healthy controls. This suggests a potential dysregulation in proteolysis associated with AIDS.

Area of Science:

  • Biochemistry
  • Immunology
  • Hematology

Background:

  • Plasmin plays a crucial role in fibrinolysis.
  • Urokinase (UK) is a key activator of plasmin.
  • Dysregulation of proteolysis is implicated in various diseases.

Purpose of the Study:

  • To investigate the effect of serum from acquired immunodeficiency syndrome (AIDS) patients on urokinase (UK)-induced plasmin activity.
  • To compare the inhibitory capacity of serum from AIDS patients versus healthy controls.

Main Methods:

  • Fibrin plate assay using 125I-fibrin coated plates.
  • Incubation of plates with UK or trypsin in the presence of serum from AIDS patients or healthy controls.
  • Measurement of released radioactivity to quantify plasmin activity and inhibition.

Related Experiment Videos

Main Results:

  • Healthy control sera completely abrogated UK-induced plasmin activation (>98%).
  • Serum from approximately 50% of AIDS patients showed significantly reduced inhibition (to 26%).
  • The reduced inhibition in AIDS patient serum was specific to UK-induced plasmin activation and not trypsin activity.

Conclusions:

  • AIDS patient serum exhibits a diminished capacity to inhibit UK-dependent plasmin activation.
  • These findings suggest a potential dysregulation of UK-dependent proteolysis in AIDS.
  • An acid-stable inhibitor present in healthy control serum was not detected in AIDS patient serum.