[The effects of dl-sotalol on the urinary osmolarity of anesthetized dogs]

The effect of dl-sotalol (intrarenal perfusion of 19 mg/kg during 30 min) on urinary concentration was studied under pentobarbital anaesthesia in dehydrated dogs. Sotalol infusion decreased urinary osmolality and increased natriuresis and urine flow. This diuretic action was accompanied by the reduction of the renin hypersecretion elicited by water deprivation.