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Reversible megaesophagus associated with atypical primary hypoadrenocorticism in a dog
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
Journal of the American Veterinary Medical Association
|September 15, 1992
Summary
A Standard Poodle with megaesophagus, hypercalcemia, and eosinophilia recovered after glucocorticoid replacement therapy. This case suggests an underlying immunologic disorder contributing to the endocrinopathy.
Area of Science:
- Veterinary Medicine
- Endocrinology
- Immunology
Background:
- Glucocorticoid deficiency can manifest with diverse clinical signs.
- Concurrent endocrine diseases, like hypothyroidism, may complicate diagnosis.
- Standard Poodles are predisposed to certain immune-mediated conditions.
Observation:
- A 5-year-old Standard Poodle presented with megaesophagus, hypercalcemia, and eosinophilia.
- These clinical and biochemical abnormalities were linked to glucocorticoid deficiency.
- The dog also had concurrent hypothyroidism.
Findings:
- Glucocorticoid replacement therapy led to the resolution of clinical and biochemical abnormalities.
- The patient remained clinically normal for 29 months post-diagnosis.
- The breed, sex, and presence of a second endocrinopathy suggested an underlying immune-mediated disorder.
Implications:
- This case highlights the importance of considering immune-mediated diseases in dogs with complex endocrinopathies.
- Successful glucocorticoid replacement therapy can effectively manage such conditions.
- Further research into the link between endocrinopathies and immune disorders in dogs is warranted.