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Decrease in lung volume-related feedback enhances laryngeal reflexes to negative pressure.

S Zhang1, O P Mathew

  • 1Department of Pediatrics, University of Texas Medical Branch, Galveston 77550.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 1, 1992
PubMed
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Decreased lung volume feedback amplifies the upper airway muscles' response to negative pressure. This finding highlights the role of lung volume receptors in respiratory control during airway challenges.

Area of Science:

  • Respiratory Physiology
  • Neuroscience
  • Pulmonary Medicine

Background:

  • Negative pressure in the upper airway typically excites upper airway muscles.
  • The influence of lung volume feedback on this response is not fully understood.

Purpose of the Study:

  • To investigate the role of lung volume feedback, specifically from slowly adapting receptors (SARs), in modulating the response to negative upper airway pressure.

Main Methods:

  • Adult rabbits were anesthetized and spontaneously breathing.
  • Slowly adapting receptors (SARs) were blocked using sulfur dioxide (SO2) exposure.
  • Negative pressure pulses were applied to the upper airway before and after SAR blockade.
  • Electromyogram (EMG) of upper airway muscles and tracheal airflow were recorded.

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Main Results:

  • Negative pressure application increased genioglossus and alae nasi EMG activity and inspiratory duration.
  • Peak inspiratory flow decreased with negative pressure application.
  • These excitatory and inhibitory effects were significantly augmented after SAR blockade.

Conclusions:

  • A decrease in lung volume feedback enhances the excitatory response of upper airway muscles to negative pressure.
  • Slowly adapting receptors play a crucial role in modulating respiratory responses to upper airway pressure changes.