Interstitial keratitis and iridoschisis in congenital syphilis

Bilateral interstitial keratitis and iridoschisis are reported in four cases with extraocular stigmata of congenital syphilis and positive syphilis serology. The iridoschisis was extensive in two cases giving the iris an unusual ragged appearance, while it was slight in one case. Iridoschisis may suggest the diagnosis of congenital syphilis, especially when interstitial keratitis is mild. Chronic open-angle glaucoma should be excluded in all patients with interstitial keratitis and iridoschisis.