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Updated: Aug 19, 2026
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Malignant lymphoma and leukemia with prominent ulceration: clinicopathologic correlation of 33 cases
1Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
Background:
The clinical and pathologic findings in patients with malignant lymphomas who presented with prominent cutaneous ulcers are described.
Objective:
Our purpose was to determine the histologic findings, type, and prognosis of lymphomas with cutaneous ulcers.
Methods:
Thirty-three patients (20 with cutaneous T-cell lymphomas, 10 with other non-Hodgkin's lymphomas, and 3 with leukemia) were retrospectively studied.
Results:
All patients had a poor prognosis; 23 died within 9 months after the onset of the ulcers. Patients with non-Hodgkin's lymphoma had a worse prognosis, had a higher incidence of systemic involvement, and more often had ulcers as an initial manifestation of lymphoma than did the patients with cutaneous T-cell lymphoma. The histopathologic findings ranged from a nonspecific inflammatory infiltrate to ulcers with marked adjacent epidermal epidermotropism to ulcers with an angiocentric infiltrate.
Conclusion:
A variety of lymphomas may cause cutaneous ulceration. Adequate sampling of these ulcers is necessary for diagnosis. The average life expectancy after ulcer formation is 21 months.
