Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Back-diffusion--fact or fiction?

B Thjodleifsson, K G Wormsley

    Digestion
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    The study questions the interpretation of "back-diffusion" of acid as a marker for gastric mucosal damage. Current evidence linking acid loss and transmucosal potential difference to mucosal injury is insufficient.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Stability of the irritable bowel syndrome and subgroups as measured by three diagnostic criteria - a 10-year follow-up study.

    Alimentary pharmacology & therapeutics·2010
    Same author

    [Epidemiology of liver cirrhosis morbitity and mortality in Iceland.].

    Laeknabladid·2010
    Same author

    [The prevalence of H. pylori antibodies in Iceland.].

    Laeknabladid·2010
    Same author

    [Helicobacter pylori infection: the efficacy of a short course of azithromycin and fleroxacin treatment.].

    Laeknabladid·2010
    Same author

    [Helicobacter pylori infection: The efficacy of bismuth-tetracyclin-metronidazole triple therapy in patients with duodenal ulcer.].

    Laeknabladid·2010
    Same author

    [Comparison of the efficacy of Losec/Lómex and Zantac/Famex by continuous 24 hour gastric pH-metry.].

    Laeknabladid·2009

    Area of Science:

    • Gastroenterology
    • Physiology
    • Biochemistry

    Background:

    • Acid back-diffusion into the gastric mucosa is often linked to mucosal damage.
    • Increased acid loss from gastric contents suggests a breakdown of the gastric mucosal barrier.
    • Changes in transmucosal potential difference are thought to indicate gastric mucosal damage.

    Purpose of the Study:

    • To critically evaluate the evidence supporting the concept of acid back-diffusion as an indicator of gastric mucosal damage.
    • To examine the assumptions underlying the interpretation of acid loss and electrical property changes in gastric mucosa.
    • To assess the validity of current hypotheses regarding gastric mucosal barrier function.

    Main Methods:

    • Literature review and critical analysis of existing hypotheses.

    Related Experiment Videos

  • Discussion of the underlying assumptions and interpretations of experimental data.
  • Examination of the relationship between acid concentration, flow rates, and mucosal integrity.

    • Main Results:

    • The interpretation of acid back-diffusion as a direct measure of mucosal damage lacks sufficient direct evidence.
    • The link between increased acid loss and mucosal barrier breakdown is based on assumptions rather than conclusive proof.
    • Alterations in transmucosal potential difference as indicators of mucosal damage are also not definitively supported by direct evidence.

    Conclusions:

    • The current hypotheses explaining gastric mucosal damage through acid back-diffusion and electrical property changes require more direct supporting evidence.
    • The concept of a gastric mucosal barrier's role in preventing acid back-diffusion needs further investigation with robust data.
    • Re-evaluation of the interpretation of physiological measurements in the context of gastric mucosal integrity is warranted.