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Updated: Sep 5, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
ATRIAL SEPTAL DEFECT IN INFANCY
Insights
This study highlights the varied presentation of atrial septal defect in infants, noting potential dangers like sudden death and failure to thrive. Early detection and monitoring are crucial for managing this congenital heart condition.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Disease
Background:
- Atrial septal defect (ASD) is a common congenital heart anomaly.
- Infantile presentation of ASD can be variable, posing diagnostic challenges.
Purpose of the Study:
- To describe the clinical features and potential complications of atrial septal defect in infancy.
- To emphasize the importance of recognizing subtle signs and potential dangers of ASD in young infants.
Main Methods:
- Retrospective case series analysis of seven infants diagnosed with atrial septal defect.
- Clinical evaluation including physical examination, electrocardiography, chest roentgenography, and cardiac catheterization.
Main Results:
- Four infants were asymptomatic, one failed to thrive, and two experienced sudden death.
- Ejection murmurs were present in five infants; two with pulmonary hypertension had loud pan-systolic murmurs.
- Cardiac catheterization confirmed a left-to-right atrial shunt in all seven infants; pulmonary hypertension was noted in two.
Conclusions:
- Atrial septal defect in infancy can present with diverse clinical manifestations, including asymptomatic cases and severe outcomes.
- Diagnostic findings like murmurs and split second heart sound evolve over time.
- Early recognition and comprehensive evaluation are vital for managing infants with atrial septal defect and associated complications like pulmonary hypertension.
Abstract:
The case histories of seven infants with atrial septal defect are presented to draw attention to certain features and possible dangers of this defect in infancy. Four infants were asymptomatic but one failed to thrive and two died suddenly. Five had ejection murmurs and two, with pulmonary hypertension, had loud pan-systolic murmurs with a thrill. In two infants murmurs were noted at birth, but in five they were first heard between the ages of 1 and 6 months. The second pulmonary sound was initially narrowly split in all, but became widely split between the ages of 12 and 20 months. Electrocardiograms and chest roentgenograms were of little help at the outset but later showed findings characteristic of the defect after one year. All infants were catheterized; a left-to-right atrial shunt was detected in each instance. Pulmonary hypertension was present in two infants, one of whom died.
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