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Updated: Jul 22, 2026
A Method for 2-Photon Imaging of Blood Flow in the Neocortex through a Cranial Window
Published on: February 25, 2008
The baboon model under anesthesia for in vivo cerebral blood flow studies using single photon emission computed
I Dormehl1, F Redelinghuys, N Hugo
1AEC Institute for Life Sciences, University of Pretoria, South Africa.
Abstract:
Single photon emission computed tomography of the brain can be useful in animal experimentation directed toward cerebral conditions. A well established and understood baboon model, necessarily under anesthesia, could be especially valuable in such investigations. Six normal baboons were studied under various anesthetic agents and their combinations: ketamine, thiopentone, pentobarbitone, and halothane. Cerebral blood flow (CBF) studies were performed with 99mTc-HMPAO. CBF effects from various anesthesia were detected, requiring careful choice of the anesthesia for cerebral investigations.
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