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FETAL HEPATIC NECROSIS IN GLANDULAR FEVER
Journal of Clinical Pathology
|July 1, 1963
Summary
Infectious mononucleosis can cause severe liver damage, leading to fatal hepatic coma. This case highlights the extreme spectrum of liver injury possible with this common viral illness.
Area of Science:
- Hepatology
- Infectious Diseases
- Pathology
Background:
- Infectious mononucleosis, typically a mild illness, is caused by the Epstein-Barr virus.
- While hepatic involvement is common, severe liver injury is rare.
Purpose of the Study:
- To report a fatal case of infectious mononucleosis with massive hepatic necrosis.
- To emphasize the potential for severe liver damage in infectious mononucleosis.
Main Methods:
- Case report of a 24-year-old male.
- Clinical presentation, laboratory findings, and post-mortem examination (necropsy) were reviewed.
Main Results:
- The patient presented with symptoms of glandular fever and jaundice.
- Necropsy revealed massive necrosis of the liver.
- The patient died in hepatic coma.
Conclusions:
- Infectious mononucleosis can lead to fulminant hepatic failure.
- All grades of liver damage severity are possible in infectious mononucleosis.
- This case underscores the importance of considering severe liver injury in patients with infectious mononucleosis.