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[Eosinophilia-myalgia syndrome].

S Kotake¹, S Kashiwazaki

¹Institute of Rheumatology, Tokyo Women's Medical College.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|July 1, 1992

Summary

Eosinophilia-myalgia syndrome (EMS), linked to L-tryptophan supplements, caused over 1500 cases and 31 deaths. Research reviews clinical and pathological features, seeking to understand its cause and potential links to scleroderma.

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Area of Science:

Immunology
Toxicology
Epidemiology

Context:

Eosinophilia-myalgia syndrome (EMS) is a newly identified multisystemic illness.
Characterized by marked peripheral eosinophilia and scleroderma-like skin changes.
Over 1500 cases, including 31 fatalities, were reported by July 1991.

Purpose:

To review recent advances in understanding the clinical and pathological features of EMS.
To explore the association between EMS and L-tryptophan (LT) ingestion.
To discuss the potential insights EMS research offers for scleroderma and eosinophilic fasciitis.

Summary:

Epidemiological data strongly suggest a link between EMS and LT contaminated by a single manufacturer.
The precise pathogenesis of EMS remains incompletely understood.
Clinical manifestations include myalgia, arthralgia, peripheral neuropathy, and skin changes.

Impact:

Understanding EMS pathogenesis may provide insights into related fibrotic conditions.
Highlights the importance of contaminant identification in pharmaceutical products.
Contributed to regulatory actions and public health advisories regarding dietary supplements.

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