Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haemodynamic alterations and their morphological basis in biliary obstruction.

Y Shibayama1, K Nakata

  • 1Department of Pathology, Osaka Medical College, Japan.

Liver
|August 1, 1992
PubMed
Summary

Biliary obstruction in rats elevates portal vein pressure, causing liver circulatory issues. Morphological changes like portal vein narrowing and sinusoidal stenosis disrupt blood flow, impacting liver function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.

Biochemical and biophysical research communications·1999
Same author

Prevalence and characterization of hepatitis C virus in hemodialysis patients.

Internal medicine (Tokyo, Japan)·1999
Same author

Epidermal growth factor-mediated cell maturation and apoptosis in RGM-1 rat gastric mucosal cells.

International journal of molecular medicine·1999
Same author

Long-term in vivo left ventricular assist device study for 284 days with Gyro PI pump.

Artificial organs·1999
Same author

Cytokine and endothelial damage in pulsatile and nonpulsatile cardiopulmonary bypass.

Artificial organs·1999
Same author

A new control method that estimates the backflow in a centrifugal pump.

Artificial organs·1999

Area of Science:

  • Hepatology
  • Vascular Biology
  • Surgical Pathology

Background:

  • Biliary obstruction is a common clinical condition.
  • Understanding its impact on liver hemodynamics and morphology is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the relationship between hemodynamic alterations and morphological changes in the liver following biliary obstruction.
  • To elucidate the mechanisms of hepatic circulatory disturbance in this condition.

Main Methods:

  • Induction of biliary obstruction via common bile duct ligation in a rat model.
  • Measurement of portal vein pressure and pressure gradients within the liver vasculature.
  • Histopathological examination of liver tissue to assess morphological changes.

Related Experiment Videos

Main Results:

  • Common bile duct ligation resulted in markedly elevated portal vein pressure in rats.
  • Increased pressure differences were observed between portal vein segments and hepatic venules.
  • Liver morphology showed narrowing of peripheral portal vein branches and sinusoidal stenosis due to enlarged hepatocytes.

Conclusions:

  • Hepatic circulatory disturbance in biliary obstruction is attributed to the deformation of peripheral portal vein branches.
  • Sinusoidal stenosis, caused by enlarged liver cells, further contributes to impaired blood flow.
  • These findings highlight the complex interplay between obstruction, vascular changes, and liver structure.