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[Chorea and primary antiphospholipid syndrome].

H A van Heereveld¹, F H van den Hoogen, G de Vaan

¹Afd. Interne Geneeskunde, Academisch Ziekenhuis St. Radboud, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde

|September 26, 1992

Summary

Primary antiphospholipid syndrome (PAPS) can cause rare neurological symptoms like chorea. This study presents two cases where PAPS was the likely cause of chorea, highlighting a significant association.

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Area of Science:

Neurology
Rheumatology
Immunology

Background:

Primary antiphospholipid syndrome (PAPS) is an autoimmune disorder characterized by antiphospholipid antibodies and thrombotic events.
While various clinical manifestations exist, neurological involvement is recognized, though often rare.

Observation:

Chorea, a hyperkinetic movement disorder, is a known but infrequent complication of systemic lupus erythematosus.
Antiphospholipid antibodies are strongly associated with chorea in systemic lupus erythematosus patients.

Findings:

This report details two cases of patients presenting with chorea.
The clinical presentation suggested that primary antiphospholipid syndrome was the underlying cause of chorea in both patients.

Implications:

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These cases suggest a potential causal link between primary antiphospholipid syndrome and chorea.
Further research is warranted to explore the mechanisms and prevalence of chorea in PAPS.