[Status of the erythron during growth of induced tumors]

The authors conducted complex (with the use of radionuclide, cytospectrophotometric, electron microscopic, interfermometric, and other methods) examination of the morpho-functional condition of the central and peripheral erythron links in rats during the development of tumors induced by 20-methyl-cholanthrene administration. It was found that increased hemolysis of mature circulating red cells plays the principle role in the pathogenesis of anemia developing in the experimental animals. The early periods of the hemolysis may be detected in the latent period of cancerogenesis.