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Lymphocytic adenosine deaminase activity in typhoid fevers
1Medical College and Hospital, Rohtak, Haryana, India.
Postgraduate Medical Journal
|April 1, 1992
Summary
Lymphocyte adenosine deaminase (L-ADA) activity indicates disease severity in typhoid fever. Low L-ADA at admission suggests a complicated, prolonged illness, while elevated levels in uncomplicated cases show increased lymphocyte activity.
Area of Science:
- Immunology
- Infectious Diseases
Background:
- Typhoid fever is a significant global health concern.
- Lymphocyte adenosine deaminase (L-ADA) activity reflects lymphocyte function and immune response.
Purpose of the Study:
- To investigate the correlation between L-ADA activity and the severity of typhoid fever.
- To determine if serial L-ADA measurements can serve as a prognostic indicator in typhoid fever patients.
Main Methods:
- L-ADA activity was measured in 10 healthy controls and 30 typhoid fever patients (20 uncomplicated, 10 complicated).
- Measurements were taken at admission, during complications, and weekly until recovery.
- Statistical analysis compared L-ADA levels between groups and over time.
Main Results:
- Uncomplicated typhoid patients showed significantly higher L-ADA activity at admission compared to controls.
- Complicated typhoid patients exhibited significantly lower L-ADA activity at admission, which decreased further with complication onset.
- L-ADA activity increased in complicated cases by defervescence, surpassing control levels.
- A cut-off L-ADA activity of 24 mU/10(6) cells was proposed for prognosis.
Conclusions:
- Serial L-ADA activity measurements are valuable for predicting typhoid fever prognosis and disease severity.
- Activity below 24 mU/10(6) cells suggests a severe, prolonged course, aiding early treatment decisions.