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[Changes in the vascular wall induced by surgical glues. Experimental study]
M Portoghese1, C Acar, V Jebara
1Service de Chirurgie cardiovasculaire, Hôpital Broussais, Paris.
Presse Medicale (Paris, France : 1983)
|July 4, 1992
Summary
Gelatin-resorcinol-formaldehyde (GRF) glue caused vascular wall destruction in rats, while fibrin glue maintained normal arterial structure. Fibrin glue is recommended for fragile tissues like coronary arteries.
Area of Science:
- Vascular Surgery
- Biomaterials Science
- Histopathology
Background:
- Surgical glues are used to repair vascular tissues.
- Evaluating the biocompatibility of surgical glues is crucial for patient safety.
Purpose of the Study:
- To compare the effects of gelatin-resorcinol-formaldehyde (GRF) and fibrin surgical glues on rat abdominal aorta.
- To determine the suitability of each glue for fragile vascular tissues.
Main Methods:
- Rat abdominal aortas were exposed to GRF glue and fibrin glue (Tissucol).
- Vascular tissue architecture was examined histopathologically.
Main Results:
- GRF glue induced significant vascular wall destruction, with glue inclusions observed in the media.
- Fibrin glue preserved the normal three-layer architecture of the arterial wall.
Conclusions:
- GRF glue is associated with adverse effects on vascular tissue and should be avoided on fragile vessels.
- Fibrin glue demonstrates better biocompatibility and is preferable for use on delicate tissues, such as coronary arteries.