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[Renal aging in man].

M Godin1, B Moulin, I Etienne

  • 1Service de Néphrologie, CHRU, Rouen.

Presse Medicale (Paris, France : 1983)
|July 22, 1992
PubMed
Summary
This summary is machine-generated.

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Aging causes kidney changes, including reduced size and fewer glomeruli, impacting filtration and function. These age-related renal alterations may stem from unnoticed pathological processes rather than aging itself.

Area of Science:

  • Nephrology
  • Gerontology
  • Physiology

Context:

  • Renal mass and cortical volume decrease significantly in individuals aged 50-80.
  • Glomerular sclerosis leads to a progressive decline in the number of functional glomeruli.
  • Age-related changes affect kidney structure and function in the elderly population.

Purpose:

  • To investigate the morphological and functional changes in the aging kidney.
  • To detail the age-associated decline in glomerular filtration rate and renal plasma flow.
  • To explore the functional consequences of these changes on tubular function and renal adaptation.

Summary:

  • Renal mass decreases by 20% between ages 50-80, primarily in the cortex.
  • Glomerular filtration rate declines by 7% per decade after 40, with a 10% decrease in renal plasma flow.

Related Experiment Videos

  • Tubular function is altered, affecting sodium balance and urine concentrating ability.

    • Impact:

    • Highlights significant age-related declines in kidney function, including filtration and plasma flow.
    • Suggests that observed renal changes may be pathological rather than inevitable aging processes.
    • Provides insights into the physiological adaptations and dysregulations occurring in the aging kidney.