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Synthesis and pharmacological activity of imidazo [2,1-b] thiazole nitriles, amides and p-sulfamidophenylhydrazones
A Andreani1, M Rambaldi, A Locatelli
1Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.
Pharmaceutica Acta Helvetiae
|January 1, 1992
Abstract:
The synthesis of three series of new imidazo [2,1-b] thiazoles (nitriles 1-7, amides 8-14 and p-sulfamidophenylhydrazones 15-24) is reported. Among the compounds tested, only 12 showed a borderline diuretic activity. Compounds 15-24, possible prodrugs of sulfanilamide, were devoid of antibacterial activity.