Related Experiment Videos
[New ampicillin derivatives with glyoxyloylbenzhydrazone side chains]
L Heinisch1, K G Hanschke, H Willitzer
1Institut für Mikrobiologie und experimentelle Therapie (ZIMET), Jena.
Die Pharmazie
|June 1, 1992
Abstract:
New ampicillin derivatives were synthesized from glyoxylic acid benzhydrazones by reaction with chloroformates via mixed anhydrides and ampicillin. These compounds were tested in an agar diffusion test against six different bacterial strains and also for their stability against beta-lactamases. Studies about structure-activity relationships have shown, that the activity against different bacterial strains is influenced in different manner by hydrophilic or hydrophobic and electronic properties of substituents.