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Related Experiment Videos

Serotonergic function and late luteal phase dysphoric disorder.

A T Veeninga1, H G Westenberg

  • 1Psychiatric Hospital De Grote Rivieren, Dordrecht, The Netherlands.

Psychopharmacology
|January 1, 1992
PubMed
Summary

This study found no significant differences in serotonin (5-HT) platelet uptake or pituitary response to 5-hydroxytryptophan (5-HTP) between women with late luteal phase dysphoric disorder (LLPDD) and controls, suggesting serotonin may not play a key role in LLPDD pathophysiology.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • Late luteal phase dysphoric disorder (LLPDD) is a severe form of premenstrual syndrome.
  • Serotonin (5-HT) dysfunction has been hypothesized to contribute to LLPDD pathophysiology.
  • Platelet 5-HT uptake and pituitary-serotonin sensitivity are potential markers for 5-HT system function.

Purpose of the Study:

  • To investigate platelet 5-HT uptake kinetics in women with LLPDD compared to controls.
  • To assess pituitary sensitivity to serotonin via 5-hydroxytryptophan (5-HTP) challenge in LLPDD patients.
  • To examine the relationship between 5-HTP response and pituitary-adrenal function (cortisol and beta-endorphin secretion).

Main Methods:

  • Compared 5-HT platelet uptake and content in premenstrual and postmenstrual phases in 38 LLPDD patients and 18 controls.

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  • Administered 5-HTP to assess pituitary response and measured plasma cortisol and beta-endorphin levels pre- and post-administration.
  • Analyzed 5-HTP metabolism to rule out confounding factors.

    • Main Results:

    • LLPDD patients did not show altered platelet 5-HT uptake or content compared to controls in the premenstrual phase.
    • No significant differences were found in the pituitary-adrenal response (cortisol, beta-endorphin) to 5-HTP stimulation between LLPDD patients and controls.
    • Observed pituitary responses were not attributable to differences in 5-HTP metabolism.

    Conclusions:

    • The study findings do not support a specific role for serotonin (5-HT) in the pathophysiology of LLPDD.
    • Platelet 5-HT uptake and pituitary 5-HTP sensitivity do not appear to be distinguishing factors for LLPDD.