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Related Experiment Videos

Nasal nicotine spray: a rapid nicotine delivery system.

G Sutherland1, M A Russell, J Stapleton

  • 1ICRF Health Behaviour Unit, Institute of Psychiatry, London, UK.

Psychopharmacology
|January 1, 1992
PubMed
Summary

Two nasal nicotine spray products demonstrated rapid nicotine absorption, achieving smoking-range blood levels. Both were acceptable for smoking cessation, with users maintaining lower nicotine concentrations than from smoking.

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Area of Science:

  • Pharmacology
  • Clinical Pharmacology

Background:

  • Nicotine replacement therapy (NRT) is crucial for smoking cessation.
  • Nasal nicotine sprays offer rapid nicotine delivery, potentially mimicking smoking.
  • Understanding absorption kinetics and user experience is vital for NRT development.

Purpose of the Study:

  • To compare plasma nicotine concentrations and cardiovascular responses between two nasal nicotine spray products.
  • To assess the acceptability and nicotine delivery of nasal sprays during ad libitum use for smoking cessation.
  • To evaluate nicotine levels achieved with repeated dosing and compare them to prior smoking levels.

Main Methods:

  • Ten subjects received a single 2 mg dose of nicotine base via two different nasal spray products.
  • Plasma nicotine concentrations were measured over 5 minutes post-administration.

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  • A second study involved 9 subjects using the sprays ad libitum for 4 weeks under clinical conditions.

    • Main Results:

    • Rapid nicotine absorption was observed, with average peak increases of 10.5 ng/ml at 5 minutes.
    • No significant differences were found between the two products in nicotine levels or cardiovascular responses.
    • Subjective side effects like light-headedness were reported by 8 subjects.
    • Ad libitum use showed acceptable product use without escalation, with average nicotine levels at 44% of prior smoking levels.

    Conclusions:

    • Both nasal nicotine spray products provide rapid nicotine delivery and are comparable in efficacy and cardiovascular effects.
    • These sprays are acceptable for therapeutic use as an aid to smoking cessation.
    • Nicotine levels achieved with nasal sprays during cessation are significantly lower than those from active smoking.