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Related Experiment Videos

Clinicopathological correlations in cor pulmonale.

P M Calverley1, R Howatson, D C Flenley

  • 1Department of Medicine, University of Liverpool.

Thorax
|July 1, 1992
PubMed
Summary

Domiciliary oxygen therapy may help reverse right ventricular hypertrophy and carotid body enlargement in patients with hypoxic cor pulmonale. Physiological measurements alone are poor indicators of disease severity in these patients.

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Area of Science:

  • Cardiology
  • Pulmonology
  • Pathology

Background:

  • Controversy exists regarding pulmonary disease and physiological abnormalities in hypoxic cor pulmonale.
  • The association between arterial hypoxemia and right ventricular hypertrophy is debated.
  • This study investigated patients with hypoxic cor pulmonale treated with and without domiciliary oxygen.

Purpose of the Study:

  • To investigate the relationship between physiological disturbances and disease severity in hypoxic cor pulmonale.
  • To assess the impact of domiciliary oxygen therapy on right ventricular hypertrophy and carotid body weight.

Main Methods:

  • Retrospective analysis of necropsy data from 19 patients with hypoxic cor pulmonale.
  • Measurement of pulmonary artery pressure, vascular resistance, and blood gas tensions.
  • Assessment of emphysema, right and left ventricular weights, and carotid body weights.

Main Results:

  • Physiological measurements did not correlate with macroscopic emphysema, pulmonary hypertension, or blood gas tensions.
  • Arterial oxygen tension (PaO2) was correlated with right ventricular hypertrophy (LV&S/RV ratio) and carotid body weight in patients receiving oxygen.
  • Fourteen patients died of respiratory failure, with pulmonary artery thrombus found in eight.

Conclusions:

  • In vivo physiological disturbances are unreliable indicators of underlying disease in hypoxic cor pulmonale.
  • Domiciliary oxygen therapy may lead to regression of right ventricular hypertrophy and carotid body enlargement.
  • Further research is needed to confirm the benefits of oxygen therapy in managing hypoxic cor pulmonale.

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