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MUMPS MENINGOENCEPHALITIS, TORONTO, 1963

D M MCLEAN, R D BACH, R P LARKE

    Canadian Medical Association Journal
    |February 15, 1964
    PubMed

    Insights

    Mumps meningoencephalitis can occur without parotitis. Mumps virus was isolated from cerebrospinal fluid, and an inactivated mumps vaccine showed protective effects in unvaccinated parents.

    Area of Science:

    • Virology
    • Neurology
    • Epidemiology

    Background:

    • Mumps meningoencephalitis is a serious complication of mumps virus infection.
    • Understanding the clinical presentation and viral shedding is crucial for diagnosis and management.
    • Previous studies have explored the efficacy of mumps vaccines.

    Purpose of the Study:

    • To investigate the clinical characteristics of mumps meningoencephalitis, including salivary gland involvement.
    • To determine the rate of mumps virus isolation from cerebrospinal fluid (CSF).
    • To evaluate the protective effect of an inactivated mumps vaccine in unvaccinated parents.

    Main Methods:

    • Retrospective analysis of hospitalized children with mumps meningoencephalitis between 1959 and 1963.
    • Laboratory confirmation of mumps infection through virus isolation from CSF and serological testing (mumps antihemagglutinin).
    • Administration of inactivated mumps vaccine to parents of infected children and assessment of subsequent mumps incidence.

    Main Results:

    • Of 39 patients with laboratory-confirmed mumps, 15 had no parotitis.
    • Mumps virus was recovered from CSF in 18 of 40 patients; isolation rates peaked in winter/spring.
    • Inactivated mumps vaccine protected unvaccinated parents, with no cases in those with prevaccination antibodies.

    Conclusions:

    • Mumps meningoencephalitis can present without parotitis, highlighting the importance of laboratory diagnosis.
    • Mumps virus can be isolated from CSF, particularly during peak incidence periods.
    • Inactivated mumps vaccine appears effective in preventing mumps in susceptible individuals.
    Keywords:
    ANTIGEN-ANTIBODY REACTIONSCANADACHILDEPIDEMIOLOGYMENINGOENCEPHALITISMUMPSMUMPS VIRUSVACCINES

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