[Modulation of lipid peroxidation by biogenic amines in model systems]

Specific effects of serotonin, histamine, noradrenaline and tyramine on the rate of lipid peroxidation were studied in model systems by means of measurement of malonic dialdehyde and Schiff base concentration as well as of kinetics of O2 consumption. Alterations in the lipid peroxidation rate in the presence of biogenic amines occurred dissimilarly depending on localization of oxidation substrates either in bilayer membranes or in micellar solution. The antioxidative effect of serotonin was the most pronounced as a result of its ability to react with lipid peroxidation radicals.