[Effect of alpha-acidic glycoprotein on oxyproline metabolism in experimental thermal trauma]

alpha 1-Acid glycoprotein, isolated from human blood plasma, was shown to accelerate healing of burn wounds in rats and to increase daily urine excretion. The glycoprotein restricted an elevation of the peptide-bound hydroxyproline in blood plasma, decreased the ratio between peptide-bound and free hydroxyproline within all the periods of experiment during 3 weeks as well as stimulated hydroxyproline excretion with urine at the step of active reparation of burn wounds. The glycoprotein appears to protect connective tissue metabolism in burns.