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Updated: Jul 7, 2026
07:07
Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells
Published on: March 8, 2015
[Reticular degeneration of retinal pigment epithelium]
1Department of Ophthalmology, Hamamatsu University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi
|September 1, 1992
Summary
Reticular degeneration of the retinal pigment epithelium (RDRPE) affects over 1% of patients. This condition progresses from nasal quadrants to all peripheral retina quadrants, particularly in older individuals.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Pigment Epithelium Research
Context:
- Fluorescein angiography is a key diagnostic tool.
- Reticular degeneration of the retinal pigment epithelium (RDRPE) is a specific finding.
- Prevalence noted in 1.06% of analyzed angiograms.
Purpose:
- To characterize the prevalence and patterns of RDRPE.
- To understand the age-related progression of RDRPE.
- To investigate the relationship between RDRPE and posterior pole degeneration.
Summary:
- RDRPE identified in 33 of 3114 angiograms (1.06%), peaking in the 8th decade (avg. age 73).
- Bilateral RDRPE observed in 85% of cases.
- Early RDRPE (ages 50-70) presents as linear, incomplete polygons nasally; advanced RDRPE (>70) shows complete polygons across nasal and temporal quadrants.
Impact:
- RDRPE initially manifests nasally and progresses to a generalized pattern.
- Findings suggest RDRPE is linked to pigment epithelium degeneration at the posterior pole.
- Establishes a developmental pattern for RDRPE in peripheral retinal imaging.
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