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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

DNA CONTENTS OF CHROMOSOME PH1 AND CHROMOSOME 21 IN HUMAN CHRONIC GRANULOCYTIC LEUKEMIA

C T RUDKIN, D A HUNGERFORD, P C NOWELL

    Science (New York, N.Y.)
    |June 5, 1964
    PubMed

    The Philadelphia chromosome, characteristic of chronic granulocytic leukemia, contained 61+/-1 percent as much DNA as a number 21 (or 22) chromosome from which it is believed to be derived. The remaining 39 percent represents 0.5 percent of a diploid chromosome complement, approximately 2 x 10(7) nucleotide pairs; the method used was not sensitive enough to detect whether it had been translocated to other chromosomes.

    Keywords:
    CELL NUCLEUSCHROMOSOMESDNA, NEOPLASMGENETICSLEUKEMIA, MYELOCYTICPATHOLOGY

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