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Related Experiment Videos

Second-trimester echogenic bowel and chromosomal abnormalities.

A L Scioscia1, D H Pretorius, N E Budorick

  • 1Department of Reproductive Medicine, University of California, San Diego 92103.

American Journal of Obstetrics and Gynecology
|October 1, 1992
PubMed
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Second-trimester echogenic bowel in fetuses is linked to a higher risk of aneuploidy, particularly trisomy 21. Further genetic testing is recommended for pregnancies with this ultrasound finding.

Area of Science:

  • Prenatal diagnosis
  • Fetal medicine
  • Medical ultrasonography

Background:

  • Echogenic bowel is an ultrasound finding during pregnancy.
  • Its association with fetal aneuploidy requires further investigation.

Purpose of the Study:

  • To evaluate pregnancy outcomes in fetuses with second-trimester echogenic bowel.
  • To determine the risk of aneuploidy associated with this finding.

Main Methods:

  • Review of 22 pregnancies with prospective echogenic bowel diagnosis.
  • Karyotypic analysis in 19 cases and cystic fibrosis risk assessment in 17.
  • Retrospective grading of bowel echogenicity (mild or bright).

Main Results:

  • 27% of fetuses with echogenic bowel were aneuploid.

Related Experiment Videos

  • Trisomy 21 and trisomy 18 were detected.
  • Brightly echogenic bowel correlated with increased aneuploidy risk.

    • Conclusions:

    • Brightly echogenic bowel in the second trimester indicates a significant risk of fetal aneuploidy.
    • The finding is reproducible and warrants further genetic evaluation.