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Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
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The utilization of circulating cell-free fetal DNA testing and decrease in invasive diagnostic procedures: an

K E Pettit1, A D Hull1, L Korty1

  • 1Division of Maternal-Fetal Care and Genetics, University of California, San Diego, San Diego, CA, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association
|May 31, 2014
PubMed
Summary
This summary is machine-generated.

Circulating cell-free fetal DNA (ccffDNA) testing is primarily used by patients aged 35 and older. This non-invasive screening method significantly reduces the need for invasive diagnostic procedures.

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Area of Science:

  • Maternal-Fetal Medicine
  • Genetics
  • Obstetrics

Background:

  • Cell-free fetal DNA (ccffDNA) testing offers a non-invasive method for prenatal screening.
  • Understanding patient demographics and the impact of ccffDNA on diagnostic procedures is crucial.

Purpose of the Study:

  • To characterize the patient population undergoing ccffDNA testing.
  • To evaluate the trends in invasive diagnostic procedures following ccffDNA testing.

Main Methods:

  • Retrospective cohort study.
  • Analysis of patients undergoing ccffDNA testing from May to December 2012.
  • Comparison of invasive procedure rates before and during the study period.

Main Results:

  • 206 patients underwent ccffDNA testing; 75% were aged 35 or older.
  • 41% had positive aneuploidy screening and 38% had abnormal ultrasounds.
  • Invasive procedure rates decreased from 5.9% to 4.1% (P<0.01), with only 7% of negative ccffDNA tests leading to invasive procedures versus 60% of positive tests.

Conclusions:

  • ccffDNA testing is associated with a significant reduction in invasive diagnostic procedures.
  • The findings support ccffDNA as a tool to guide clinical decision-making and potentially decrease procedural risks.