Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

St-93 hyperglycemia in Wistar rats.

G P Thomas1, A Krishnamurthy, G S Thapar

  • 1Biology Division, I.D.P.L. Research Centre, Hyderabad, India.

Archives Internationales De Pharmacodynamie Et De Therapie
|January 1, 1992
PubMed
Summary

The alpha 2-adrenoceptor agonist St-93 increases blood glucose in rats. This hyperglycemia is mediated by alpha 2-adrenoceptors, potentially on pancreatic beta-cells, as shown by idazoxan inhibition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sexual Function After Obstetric Anal Sphincter Injuries (OASIs): A Systematic Review and Meta-Analysis.

International urogynecology journal·2026
Same author

Care pathways and anorectal evaluation for obstetric anal sphincter injury-related incontinence: A UK survey of obstetricians.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2025
Same author

Study of wave motion on the emergence of veering, locking, and coupling in periodic composite panels.

The Journal of the Acoustical Society of America·2024
Same author

Laparoscopic modified mesh rectopexy: medium-term results of a novel approach for external rectal prolapse.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2023
Same author

Are rectal prolapse repairs too diverse and complex for simple database analysis?

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2023
Same author

Long-term outcome of sacral nerve stimulation for faecal incontinence.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020

Area of Science:

  • Pharmacology
  • Endocrinology
  • Adrenergic Receptor Research

Background:

  • Alpha 2-adrenoceptors play a role in regulating physiological processes.
  • Understanding the specific mechanisms of adrenergic agonists is crucial for therapeutic development.

Purpose of the Study:

  • To investigate the effect of the alpha 2-adrenoceptor agonist St-93 on blood glucose levels in Wistar rats.
  • To elucidate the receptor mechanisms underlying St-93-induced hyperglycemia.

Main Methods:

  • Intraperitoneal administration of St-93 to Wistar rats.
  • Evaluation of blood glucose levels following St-93 administration.
  • Assessment of the effects of antagonists (prazosin, propranolol, idazoxan) and reserpine pretreatment.
  • Testing St-93 in streptozotocin-induced diabetic rat models.

Main Results:

  • St-93 caused a dose-dependent increase in blood glucose levels.
  • Idazoxan significantly inhibited the hyperglycemic effect of St-93.
  • Prazosin and propranolol did not alter the St-93-induced hyperglycemia.
  • Reserpine pretreatment had no effect on St-93's hyperglycemic action.
  • St-93 did not significantly increase blood glucose in streptozotocin-diabetic rats.

Conclusions:

  • The hyperglycemia induced by St-93 is mediated via alpha 2-adrenoceptors.
  • These alpha 2-adrenoceptors are likely located on pancreatic beta-cells.
  • St-93's action provides insight into adrenergic regulation of glucose homeostasis.

Related Experiment Videos