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Effects of mergocriptine on cerebral circulation and metabolism in cats
K Isozumi1, Y Izumi, Y Fukuuchi
1Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
Arzneimittel-Forschung
|July 1, 1992
Abstract:
Mergocriptine (CBM 36-733, CAS 81968-16-3) is an ergot alkaloid derivative and a dopaminergic agonist. Effects of mergocriptine on cerebral circulation and metabolism were examined by monitoring cerebral tissue oxygen and carbon dioxide tension (BrPO2, BrPCO2), cerebral blood flow (CBF) and blood pressure (BP) in 10 cats. Mergocriptine (10 micrograms/kg) infused into the carotid artery produced a significant increase in CBF during the administration followed by a decrease in BrPO2 in parallel with a significant decrease in BP.