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Magnetic resonance imaging cinecisternography in patients with white matter lesions

Y Fukuuchi1, T Amano1, H Shiga2

  • 1From the Departments of Radiology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 22, 2015
PubMed

Insights

Cerebrospinal fluid (CSF) flow dynamics are altered in patients with small multiple infarcts and dementia. Reduced phasic changes in third and fourth ventricle size suggest impaired CSF flow, potentially contributing to vascular dementia pathogenesis.

Area of Science:

  • Neuroimaging
  • Neurology
  • Cerebrospinal Fluid Dynamics

Background:

  • Vascular dementia is a significant cause of cognitive impairment.
  • The role of cerebrospinal fluid (CSF) dynamics in vascular dementia pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the dynamic changes in ventricular size using MRI cinecisternography.
  • To compare CSF flow dynamics between patients with vascular dementia and control subjects.

Main Methods:

  • Utilized MRI cinecisternography to compute dynamic changes in ventricular size.
  • Analyzed phasic changes in the third and fourth ventricles.
  • Compared findings in patients with small multiple infarcts, dementia, and enlarged lateral ventricles to control subjects.

Main Results:

  • Patients with small multiple infarcts and dementia exhibited reduced phasic changes in the third and/or fourth ventricle size.
  • Enlarged lateral ventricles were also associated with these altered dynamic changes.
  • These findings suggest a potential derangement in CSF flow dynamics.

Conclusions:

  • Impaired cerebrospinal fluid flow dynamics may play a role in the development of vascular dementia.
  • Altered ventricular size dynamics identified via MRI cinecisternography could serve as a biomarker.

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