Related Experiment Videos
Alkalinization of mepivacaine does not alter onset of caudal anesthesia
1Department of General Anesthesia, Cleveland Clinic Foundation, OH 44195.
Study Objective:
To determine the effect of alkalinization of mepivacaine on onset of caudal anesthesia.
Design:
Randomized, blind study.
Setting:
Colon-Rectal Surgery Service of the Tertiary Center at Cleveland Clinic Foundation.
Patients:
Young, healthy adults undergoing anal surgery.
Interventions:
Addition of bicarbonate (study group) or saline (control group) to mepivacaine.
Measurements And Main Results:
At the onset of sacral anesthesia, demographics were measured. A slightly faster onset was found in the study group (4.28 vs. 6.08 minutes), but this was not statistically significant.
Conclusions:
Alkalinization of mepivacaine does not significantly accelerate the onset of caudal anesthesia.