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[Estimation of individual renal function by Tc-DMSA-uptake (author's transl)]
Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|May 1, 1977
Summary
Technetium-99m dimercaptosuccinic acid (Tc-DMSA) uptake effectively estimates individual renal function. This nuclear medicine technique shows high correlation with unilateral renal clearance, offering a valuable clinical tool.
Area of Science:
- Nuclear Medicine
- Nephrology
- Urology
Background:
- Individual renal function estimation is crucial in nephrological-urological nuclear medicine.
- Mercury-203-chloride (Hg-Cl2) accumulation and iodohippuran uptake are established methods.
- There is a need for reliable and accessible methods for assessing renal function.
Purpose of the Study:
- To investigate the assessment of individual renal function using Technetium-99m dimercaptosuccinic acid (Tc-DMSA).
- To evaluate Tc-DMSA uptake as a new radiopharmaceutical for renal scintigraphy.
Main Methods:
- Tc-DMSA uptake was measured in over 2500 patients using a scintillation camera with computer analysis and a rectilinear scanner.
- Hippuran kinetics were registered concurrently using a scintillation camera.
- Total body clearance was determined using a modified whole body counter (Oberhausen method).
Main Results:
- A good agreement and high correlation were found between Tc-DMSA uptake (with background correction) and unilateral renal clearance.
- The study established Tc-DMSA uptake as a reliable indicator of individual renal function.
Conclusions:
- Tc-DMSA uptake is a clinically valuable and easily accessible method for assessing individual renal function.
- This method can be implemented even in institutions with simpler equipment, broadening its applicability in nuclear medicine.