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Folding kinetics of designer proteins. Application of the diffusion-collision model to a de novo designed four-helix
1Department of Physics, Tufts University, Medford, Massachusetts 02155.
Biophysical Journal
|July 1, 1992
Abstract:
A folding algorithm is described, based on the diffusion-collision model, combining static and dynamic calculational methods. The algorithm is applied to predict the basic structure and schematic folding pathways of an artificial four-helix bundle.