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Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
Published on: November 29, 2016
Ras proteins in developmental pattern formation in Caenorhabditis elegans and Drosophila
1Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309.
Abstract:
Recent studies of genetically isolated mutants in Caenorhabditis elegans and Drosophila have revealed ras functions in developmental pattern formation. The ras proteins act as genetic switches to determine cell fates between two alternative choices during C elegans vulval development (vulval versus hypodermal cells) and during Drosophila eye development (R7 versus cone cell). In both cases, ras proteins act downstream of a receptor tyrosine kinase in a signal transduction pathway that mediates cell-cell interactions. These genetic systems may allow the further elucidation of ras-mediated developmental regulatory pathways.

