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Oral gentamicin is not effective treatment for persistent diarrhea
A V Bartlett1, B Torun, C Morales
1Department of International Health, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland.
Acta Paediatrica (Oslo, Norway : 1992). Supplement
|September 1, 1992
Summary
Oral gentamicin did not improve cure rates for persistent diarrhea in Guatemalan children. This randomized trial found no significant difference between gentamicin and placebo treatments for childhood diarrhea.
Area of Science:
- Pediatrics
- Infectious Diseases
- Clinical Pharmacology
Background:
- Persistent diarrhea is a significant cause of morbidity in young children.
- Enteroadherent Escherichia coli and duodenal microbial colonization are potential factors in persistent diarrhea.
Purpose of the Study:
- To evaluate the efficacy of oral gentamicin in treating persistent diarrhea in young children.
- To investigate the role of specific enteropathogens and duodenal colonization in treatment outcomes.
Main Methods:
- A randomized, double-blind, placebo-controlled trial was conducted.
- Oral gentamicin (10 mg/kg/day for 5 days) or placebo was administered to children aged 3-36 months.
- Diarrhea status was monitored daily during treatment and for two days post-treatment.
Main Results:
- No significant difference in cure rates was observed between gentamicin (42%) and placebo (43%) groups.
- Enteroadherent E. coli and duodenal microbial colonization did not differ significantly between groups.
- Gentamicin resistance did not explain treatment failure.
Conclusions:
- Oral gentamicin is not effective for treating persistent diarrhea in this pediatric population.
- Further research is needed to identify effective treatments for persistent childhood diarrhea.
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