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Fungal infections
1University of Michigan Medical School, Ann Arbor.
Abstract:
Increased travel and outdoor leisure activities place the elderly individual at risk for infection with the endemic mycoses, histoplasmosis, blastomycosis, coccidioidomycoses, and sporotrichosis. Elderly patients who are immunosuppressed are at risk for infection with the opportunistic fungi such as Candida and Aspergillus. In this article, the clinical manifestations and the approach to diagnosis are discussed. The use of antifungal agents that are currently available to treat severe fungal infections also are reviewed.
Insights
Elderly individuals face increased risks of endemic and opportunistic fungal infections due to travel and immunosuppression. This review covers clinical signs, diagnosis, and current antifungal treatments for these severe infections.
Area of Science:
- Mycology
- Infectious Diseases
- Geriatrics
Background:
- Elderly individuals are increasingly susceptible to fungal infections.
- Travel and outdoor activities elevate risks for endemic mycoses like histoplasmosis and coccidioidomycosis.
- Immunosuppressed elderly patients are vulnerable to opportunistic fungi, including Candida and Aspergillus.
Purpose of the Study:
- To review the clinical manifestations of fungal infections in the elderly.
- To discuss diagnostic approaches for fungal infections in this demographic.
- To provide an overview of currently available antifungal agents for severe fungal infections.
Main Methods:
- Literature review of endemic and opportunistic mycoses in the elderly.
- Discussion of clinical presentations and diagnostic strategies.
- Review of antifungal therapies for severe fungal infections.
Main Results:
- Fungal infections pose significant risks to the elderly, particularly those who travel or are immunocompromised.
- Early diagnosis and appropriate antifungal treatment are crucial for managing severe cases.
- A range of antifungal agents are available, requiring careful selection based on the specific pathogen and patient factors.
Conclusions:
- The elderly population requires specific attention regarding fungal infection risks.
- Comprehensive diagnostic evaluation is essential for timely and effective treatment.
- Understanding current antifungal armamentarium is key to managing severe mycoses in older adults.