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Computer simulation of agglomeration in the Wurster process.

Y Fukumori1, H Ichikawa, K Jono

  • 1Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.

Chemical & Pharmaceutical Bulletin
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

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Computer simulations revealed that even a small fraction of large droplets in Wurster coating can cause significant agglomeration. Particle agitation suppresses agglomerate growth, but up to 50% agglomeration can still occur.

Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Materials Science

Background:

  • Agglomeration is a common issue in pharmaceutical coating processes like Wurster coating.
  • Controlling particle size and droplet characteristics is crucial for preventing agglomeration.
  • Understanding the relationship between droplet size and agglomerate formation is key to process optimization.

Purpose of the Study:

  • To develop a simplified computer model for simulating agglomeration in Wurster coating.
  • To investigate the influence of droplet size distribution and core particle size on agglomeration.
  • To identify the critical droplet size responsible for significant agglomeration.

Main Methods:

  • Experimental determination of droplet size distribution and agglomerate-particle relationships.

Related Experiment Videos

  • Development of a computer simulation model for Wurster coating agglomeration.
  • Simulation of coating processes using hydroxypropyl cellulose solution on various lactose powder sizes (32-75 microns).

    • Main Results:

    • Agglomeration was significantly suppressed by particle agitation for cores larger than 53 microns, yet still reached ~50%.
    • The critical droplet size for agglomeration ranged from 37.1-49.0 microns, increasing with core size.
    • A small weight fraction (0.5-2.7%) of droplets exceeding the critical size was sufficient to cause substantial agglomeration.

    Conclusions:

    • A minor proportion of coarse droplets can disproportionately drive agglomeration in Wurster coating.
    • The critical droplet size is dependent on the core particle size, highlighting the need for precise spray control.
    • The developed simulation model provides a valuable tool for optimizing coating processes and mitigating agglomeration.